Synthesis, the antibacterial and antifungal action of 4-aminopyrazolo[1,5-a]pyrazines

synthesis and antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives

Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents

BACKGROUND Thiazolidine-2, 4-diones (TZDs) have become a pharmacologically important class of heterocyclic compounds since their introduction in the form of glitazones into the clinical use for the treatment of type 2 diabetes. TZDs lower the plasma glucose levels by acting as ligands for gamma peroxisome proliferators-activated receptors. In addition, this class of heterocyclic compounds posse...

Synthesis, antibacterial and antifungal activities of some newer cephlosporin derivatives

7-(D-5-Amino-5-carboxy-valeramido)-3-(acetylhydrazido)-8-oxo-5-thio-1-azabicyclo [4,2,0]-oct2-ene-2-carboxylic acid (1). 7-(D-5-Amino-5-carboxy-valeramido)-3-(substitutedarylacetylhydrazido)8-oxo-5-thio-1-azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid.(2-5). 7-(D-5Amino-5carboxyvaleramido)3(2'substituted aryl-3'-chloro-4'-oxo-azetidin-1'-yl)-acetylamino]-8-oxo-5-thio-1azabicyclo[4,2,0]-oct-2-ene...

Synthesis, antibacterial and antifungal evaluation of norfloxacin derivatives

A series of different N-4-piperazinyl derivatives of norfloxacin was synthesized and screened for their antibacterial, antifungal and cytotoxic activities to monitor the variation in therapeutic effects of parent molecule. Result revealed that some of the tested compounds showed comparable or better activity than norfloxacin against Gram positive bacteria and Gram negative bacteria. The structu...

Synthesis, characterization, antibacterial and antifungal evaluation of novel monosaccharide esters.

A novel series of 3-(2-furyl)acrylate monosaccharide esters Ia–f and menthyloxycarbonyl monosaccharide esters IIa–f were designed and synthesized. The chemical structures of the target compounds were confirmed by IR, ¹H- and ¹³C-NMR and ESI-MS, and the target compounds were investigated for their in vitro antibacterial and antifungal activities. The antibacterial screening results showed that t...